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Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory

Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 256-264 doi: 10.1007/s11684-009-0052-3

Abstract: More and more molecular drugs based on targeted therapy have been utilized in the treatment of gynecologic

Keywords： target therapy     gynecologic malignant tumors     clinical trail     molecular medicine    

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The Preliminary Study On Malignant Tumors Effects of High Intensive Focused Ultrasound——A Primary ClinicalReport On 78 Cases of Malignant Turmors in HIFU Therapy

He Shenxu,Xiong Liulin,Yu Jinsheng,Lan Jiang

Strategic Study of CAE 1999, Volume 1, Issue 2,   Pages 62-66

Abstract: Methods 78 cases malignant tumors in abdomen and pelvis were classified into two groups： hollow organictumors group such as carcinomas of ractum and bladder etc. and solid organic tumors group such as carcinomasResults In 32 cases of hollow organic tumors, CR (Complete Remission) is 65. 6%, PR (Partial RemissionIn 46 cases of solid organic tumors, marked effect rate is 15. 6%, effect rate is 80. 4%, and non-effectConclusions The HIFU is a kind of safe and effective method to treat abdominal malignant tumor, worth

Keywords： malignant tumor     pyrotherapy     extracorporeal focused     ultrasound    

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Possibility of women treated with fertility-sparing surgery for non-epithelial ovarian tumors to safely

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 509-517 doi: 10.1007/s11684-017-0554-3

Abstract: outcomes of childbearing-age women treated with fertility-sparing surgery (FSS) for non-epithelial ovarian tumorsNon-epithelial ovarian tumors can achieve fulfilling prognosis after FSS and chemotherapy.

Keywords： malignant germ cell tumors     ovarian sex cord-stromal tumors     fertility-sparing surgery     prognosis     fertility    

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Rare tumors: a blue ocean of investigation

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 220-230 doi: 10.1007/s11684-023-0984-z

Abstract: Although rare tumors account for a non-negligible number, the practice of precision medicine and developmentHerein, by reviewing the epidemiological data of Chinese solid tumors and publications defining raretumors in other areas, we proposed a definition of rare tumor in China, including 515 tumor types withLastly, we pinpointed the current recommendation chance for patients with rare tumors to be involved

Keywords： rare tumors     diagnosis flowchart     treatment strategy     clinical trials recommendation    

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Progress on molecular biomarkers and classification of malignant gliomas

Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Tao Jiang

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 150-156 doi: 10.1007/s11684-013-0267-1

Abstract:

Gliomas are the most common primary intracranial tumors in adults.Anaplastic gliomas (WHO grade III) and glioblastomas (WHO grade IV) represent the major groups of malignantSeveral diagnostic, predictive, and prognostic biomarkers for malignant gliomas have been reported overbiomarkers, three most commonly altered pathways, and three classifications based on microarray data in malignant

Keywords： malignant glioma     molecular biomarker     IDH1     MGMT     molecular classification    

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Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 3,   Pages 333-344 doi: 10.1007/s11705-021-2059-5

Abstract: first discusses the temperature-gradient and the spatially-structured immunological landscape in solid tumors

Keywords： nano-enabled hyperthermia     immunogenic cell death     heterogeneous immunological landscape     tumor microenvironment    

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Minimal residual disease in solid tumors: an overview

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 649-674 doi: 10.1007/s11684-023-1018-6

Abstract: residual disease (MRD) is termed as the small numbers of remnant tumor cells in a subset of patients with tumorsand strategies for the detection of cancer, and emphasizes the application of MRD detection in solid tumors

Keywords： MRD     solid tumor     CTC     ctDNA    

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Change and significance of T-cell subsets and TNF-α in patients with advanced malignant obstructive jaundice

ZHU Lidong, CHEN Xiaoping

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 364-368 doi: 10.1007/s11684-007-0070-y

Abstract: The aim of this article was to study the influence of immunity function of advanced malignant obstructive
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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Frontiers of Medicine   Pages 805-822 doi: 10.1007/s11684-023-1025-7

Abstract: Immunotherapies based on immune checkpoint blockade (ICB) have significantly improved patient outcomes and offered new approaches to cancer therapy over the past decade. To date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapy. Blockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers, however, a large subset of refractory patients presents poor responsiveness to ICB therapy; and the underlying mechanism remains elusive. Recently, numerous studies have revealed that metabolic reprogramming of tumor cells restrains immune responses by remodeling the tumor microenvironment (TME) with various products of metabolism, and combination therapies involving metabolic inhibitors and ICIs provide new approaches to cancer therapy. Nevertheless, a systematic summary is lacking regarding the manner by which different targetable metabolic pathways regulate immune checkpoints to overcome ICI resistance. Here, we demonstrate the generalized mechanism of targeting cancer metabolism at three crucial immune checkpoints (CTLA-4, PD-1, and PD-L1) to influence ICB therapy and propose potential combined immunotherapeutic strategies co-targeting tumor metabolic pathways and immune checkpoints.

Keywords： CTLA-4     PD-1     PD-L1     immune checkpoint blockade (ICB)     metabolic reprogramming     combined tumor therapeutic strategies    

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monoamine transporter 2 genes for increased retention of metaiodobenzylguanidine labeled with iodine 131 in malignant

Yanlin Zhao,Xiao Zhong,Xiaohong Ou,Huawei Cai,Xiaoai Wu,Rui Huang

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 120-128 doi: 10.1007/s11684-017-0501-3

Abstract: /sup>I-MIBG both in vitro and in vivo in mice bearing transfected tumors In vivo experiments were performed in nude mice bearing transfected tumors; resultsrevealed that NET-VMAT2-coexpressing tumors had longer 131I-MIBGretention time than NET-expressing tumors.Meanwhile, NET-VMAT2-coexpressing and NET-expressing tumors displayed

Keywords： norepinephrine transporter     vesicular monoamine transporter 2     -MIBG     gene therapy     lentivirus vector    

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High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas

Frontiers of Medicine   Pages 907-923 doi: 10.1007/s11684-023-1009-7

Abstract: The characteristic genetic abnormality of neuroendocrine neoplasms (NENs), a heterogeneous group of tumorsWe tested FAK variants in 157 tumor samples collected from Chinese patients with pancreatic tumorsrepetitive matrix protein 4 (SRRM4) was overexpressed in FAK6/7-positive pancreatic tumorsand breast tumors, which promoted the formation of FAK6/7 in cells.

Keywords： FAK6/7     SRRM4     neuroendocrine neoplasms     pancreas     breast    

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Prognostic significance of clinicopathologic parameters in gastrointestinal stromal tumors: a study of

LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 87-94 doi: 10.1007/s11684-008-0016-z

Abstract: The biological behavior of gastrointestinal stromal tumors (GISTs) are highly variable.
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Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors

Qinggang Hu, Shanglong Liu, Jianwei Jiang, Chen Zhang, Xiaowei Liu, Qichang Zheng

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 317-321 doi: 10.1007/s11684-012-0203-9

Abstract:

In order to find out the potential indicators predicting prognosis of malignant gastrointestinal stromaltumors (GISTs) after surgical resection, we collected clinical records of 80 patients with malignantTumor location, size, mitotic index, necrosis were compared with the prognosis of malignant GISTs bywith mitotic index≤5/50 HPF had a higher 3-year survival rate than tumors with mitotic index>5The presence of necrosis was directly related to the malignant behavior.

Keywords： gastrointestinal stromal tumors     surgery     survival    

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Retrospective study of the efficacy and complication of thoracoabdominal incision for nephrectomy: a comparison with flank approach

Minggen YANG, Xiaokun ZHAO

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 191-196 doi: 10.1007/s11684-009-0026-5

Abstract: thoracoabdominal incision flank incision for radical nephrectomy in the patients with large renal tumorsThe mean size of tumors in group 1 was significantly smaller than that in group 2 ( < 0.0005).

Keywords： surgery     renal tumors     nephrectomy    

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Relationship of adrenomedullin expression and microvessel density and prognosis in smooth muscle tumor of uterus

JIANG Yuan, TIAN Xuehong, YUAN Jie, JIN Yuemei, TAN Yusong

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 398-400 doi: 10.1007/s11684-007-0077-4

Abstract: The ADM can be used as an accessory marker in estimating the malignant potency of LE and judging the

Keywords： anticarcinogenic     microvessel density     malignant potency     muscle     uterine leiomyosarcoma    

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Title Author Date Type Operation

Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory

Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,

Journal Article

The Preliminary Study On Malignant Tumors Effects of High Intensive Focused Ultrasound——A Primary ClinicalReport On 78 Cases of Malignant Turmors in HIFU Therapy

He Shenxu,Xiong Liulin,Yu Jinsheng,Lan Jiang

Journal Article

Possibility of women treated with fertility-sparing surgery for non-epithelial ovarian tumors to safely

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

Journal Article

Rare tumors: a blue ocean of investigation

Journal Article

Progress on molecular biomarkers and classification of malignant gliomas

Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Tao Jiang

Journal Article

Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

Journal Article

Minimal residual disease in solid tumors: an overview

Journal Article

Change and significance of T-cell subsets and TNF-α in patients with advanced malignant obstructive jaundice

ZHU Lidong, CHEN Xiaoping

Journal Article

Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Journal Article

monoamine transporter 2 genes for increased retention of metaiodobenzylguanidine labeled with iodine 131 in malignant

Yanlin Zhao,Xiao Zhong,Xiaohong Ou,Huawei Cai,Xiaoai Wu,Rui Huang

Journal Article

High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas

Journal Article

Prognostic significance of clinicopathologic parameters in gastrointestinal stromal tumors: a study of

LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei

Journal Article

Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors

Qinggang Hu, Shanglong Liu, Jianwei Jiang, Chen Zhang, Xiaowei Liu, Qichang Zheng

Journal Article

Retrospective study of the efficacy and complication of thoracoabdominal incision for nephrectomy: a comparison with flank approach

Minggen YANG, Xiaokun ZHAO

Journal Article

Relationship of adrenomedullin expression and microvessel density and prognosis in smooth muscle tumor of uterus

JIANG Yuan, TIAN Xuehong, YUAN Jie, JIN Yuemei, TAN Yusong

Journal Article